Research
Metabolic adaptation
High-dose semaglutide has favorable effects on cardiometabolic risk factors.
High-dose semaglutide may improve patients' overall cardiometabolic health.
StrongSupportsmedium confidence
Secondary outcomes demonstrated cardiometabolic improvements including waist circumference, systolic blood pressure, and lipid profiles.
Why this rating
Based on results from the same phase 3 trials.
Source
High-Dose Once-Weekly Semaglutide: A New Option for Obesity Management
Courtney L. Bradley et al. · Annals of Pharmacotherapy · 2021
DOI 10.1177/10600280211053867
reviewCited 13×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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