Research
Energy balance
The 5:2 total diet replacement (5:2TDR) resulted in a weight loss of -0.9 kg after 26 weeks, while the once-daily meal-replacement (DMR) group experienced a weight regain of 3.5 kg, leading to a between-group difference of -4.4 kg.
Practitioners may consider recommending 5:2TDR for better weight maintenance outcomes compared to DMR.
StrongSupportsmedium confidence
After 26-weeks WLM, intention-to-treat analysis found further weight-loss -0·9 kg with 5:2TDR and regain with DMR 3·5 kg; between-group difference -4·4 kg, p = 0·005.
Why this rating
Based on the randomized trial design and statistical analysis.
Source
Diet strategies for maintaining substantial therapeutic weight loss: 78-week mixed methods randomised trial
Naomi Brosnahan et al. · Clinical Nutrition · 2025
DOI 10.1016/j.clnu.2025.08.009
rct · n=63Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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