Research
Energy balance
Both dietary interventions (5:2TDR and DMR) maintained weight losses greater than 15 kg below baseline at 26, 52, and 78 weeks.
Both interventions can be effective for long-term weight maintenance.
StrongSupportsmedium confidence
Both groups maintained weight losses >15 kg below baseline at 26, 52 and 78-weeks.
Why this rating
Based on the randomized trial design and follow-up data.
Source
Diet strategies for maintaining substantial therapeutic weight loss: 78-week mixed methods randomised trial
Naomi Brosnahan et al. · Clinical Nutrition · 2025
DOI 10.1016/j.clnu.2025.08.009
rct · n=63Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The 5:2 total diet replacement (5:2TDR) resulted in a weight loss of -0.9 kg after 26 weeks, while the once-daily meal-replacement (DMR) group experienced a weight regain of 3.5 kg, leading to a between-group difference of -4.4 kg.Strong
- Structured dietary weight-loss maintenance (WLM) is well accepted by participants.Strong
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