Research
Energy balance
Lifestyle interventions showed comparable proportional lean mass loss (26.2%) to incretin therapies (p = 0.42 for comparison).
Lifestyle interventions can be as effective as incretin therapies in preserving lean mass during weight loss.
StrongSupportsmedium confidence
Lifestyle interventions showed comparable proportional lean mass loss (26.2% [24.1–28.3]; p = 0.42 for comparison).
Why this rating
Based on a systematic review and meta-analysis of randomised controlled trials.
Source
Lean Mass Changes With Incretin Therapy Versus Lifestyle Intervention: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials
Naseem Eisa et al. · Diabetes Obesity and Metabolism · 2026
DOI 10.1111/dom.70666
Meta-analysisCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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