Research
Metabolic adaptation
A high glycemic index diet is associated with an increased risk of death from cardiovascular causes.
High glycemic index diets may increase the risk of cardiovascular mortality, suggesting dietary modifications could be beneficial.
StrongSupportsmedium confidence
Among the components of the primary outcome, a high glycemic index was also associated with an increased risk of death from cardiovascular causes.
Why this rating
Based on the large sample size and study design.
Source
Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality
David J.A. Jenkins et al. · New England Journal of Medicine · 2021
DOI 10.1056/nejmoa2007123
cohort · n=137851Cited 224×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A diet with a high glycemic index is associated with an increased risk of a major cardiovascular event or death, with a hazard ratio of 1.51 among participants with preexisting cardiovascular disease and 1.21 among those without such disease.Strong
- The association between glycemic load and cardiovascular events was similar to that of glycemic index among participants with cardiovascular disease at baseline, but not significant among those without preexisting cardiovascular disease.Strong
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