Research
Metabolic adaptation
In obese patients with noninsulin-dependent diabetes mellitus (NIDDM), a 7-day period of calorie restriction produces substantial decreases in fasting plasma glucose, hepatic glucose production (HGP), and fasting plasma triglyceride, and increases in insulin sensitivity and secretion.
Calorie restriction can be an effective strategy for improving metabolic control in obese NIDDM patients.
StrongSupportsmedium confidence
The initial brief interval of calorie restriction produced substantial decreases in fasting plasma glucose, HGP, and fasting plasma triglyceride and increases in insulin sensitivity and secretion.
Why this rating
Based on the controlled study design involving direct measurements.
Source
Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus.
David E. Kelley et al. · The Journal of Clinical Endocrinology & Metabolism · 1993
other · n=7Cited 122×
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