Research
Metabolic adaptation
After substantial weight loss (12.7 +/- 2 kg), metabolic parameters improved further, with the effect of weight loss approximately equal to that obtained with initial calorie restriction.
Weight loss is equally important as calorie restriction for improving metabolic health in obese NIDDM patients.
StrongSupportsmedium confidence
After a substantial weight loss (12.7 +/- 2 kg), each parameter improved further, with the effect of weight loss approximately equal to that obtained with initial calorie restriction.
Why this rating
Based on the controlled study design involving direct measurements.
Source
Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus.
David E. Kelley et al. · The Journal of Clinical Endocrinology & Metabolism · 1993
DOI 10.1210/jcem.77.5.8077323
other · n=7Cited 122×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- In obese patients with noninsulin-dependent diabetes mellitus (NIDDM), a 7-day period of calorie restriction produces substantial decreases in fasting plasma glucose, hepatic glucose production (HGP), and fasting plasma triglyceride, and increases in insulin sensitivity and secretion.Strong
- Reimposing calorie restriction after weight loss had little effect, except that fasting plasma glucose and HGP improved slightly further.Strong
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