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The association of sitting time with the composite outcome is stronger in low-income and lower-middle-income countries (HR, 1.29; 95% CI, 1.16-1.44) compared to high-income and upper-middle-income countries (HR, 1.08; 95% CI, 0.98-1.19).
Public health strategies should focus on reducing sitting time, especially in low-income countries.
StrongSupportsmedium confidence
When stratified by country income levels, the association of sitting time with the composite outcome was stronger in low-income and lower-middle-income countries (≥8 hours per day: HR, 1.29; 95% CI, 1.16-1.44) compared with high-income and upper-middle-income countries (HR, 1.08; 95% CI, 0.98-1.19; P for interaction = .02).
Why this rating
Based on the large cohort study design.
Source
Association of Sitting Time With Mortality and Cardiovascular Events in High-Income, Middle-Income, and Low-Income Countries
Sidong Li et al. · JAMA Cardiology · 2022
DOI 10.1001/jamacardio.2022.1581
cohort · n=105677Cited 128×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Higher sitting time (≥8 hours per day) is associated with an increased risk of all-cause mortality (HR, 1.20; 95% CI, 1.10-1.31) and major cardiovascular disease (HR, 1.21; 95% CI, 1.10-1.34).Strong
- Participants who sat for 8 or more hours per day experienced a 17% to 50% higher associated risk of the composite outcome across physical activity levels.Strong
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