Research
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Semaglutide is associated with significant weight reductions primarily due to fat mass loss.
Practitioners can expect semaglutide to primarily aid in fat loss for overweight or obese patients.
StrongSupportsmedium confidence
Significant weight reductions were observed primarily due to fat mass loss.
Why this rating
Based on the systematic review of multiple studies.
Source
A systematic review of the effect of semaglutide on lean mass: insights from clinical trials
Alexia Bikou et al. · Expert Opinion on Pharmacotherapy · 2024
DOI 10.1080/14656566.2024.2343092
systematic_review · n=1541Cited 68×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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