Research
Cellular
Lean mass remained stable in some cases, but notable reductions were observed in others, ranging from almost 0% to 40% of total weight reduction.
Clinicians should monitor lean mass changes in patients using semaglutide, as results can vary significantly.
StrongQualifiesmedium confidence
While the lean mass remained stable in some cases, notable reductions ranging from almost 0% to 40% of total weight reduction were observed in others.
Why this rating
Based on the systematic review of multiple studies.
Source
A systematic review of the effect of semaglutide on lean mass: insights from clinical trials
Alexia Bikou et al. · Expert Opinion on Pharmacotherapy · 2024
DOI 10.1080/14656566.2024.2343092
systematic_review · n=1541Cited 68×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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