Research
Metabolic adaptation
Serum acylcarnitines increase with caloric restriction alone but not with caloric restriction plus exercise despite similar weight loss.
Practitioners should note that caloric restriction alone may lead to different metabolic responses compared to caloric restriction combined with exercise.
StrongSupportsmedium confidence
Despite similar weight loss, serum ACs increase with CR alone but not CR+EX.
Why this rating
Based on the randomized controlled trial design.
Source
Effect of Caloric Restriction with and without Exercise on Metabolic Intermediates in Nonobese Men and Women
Leanne M. Redman et al. · The Journal of Clinical Endocrinology & Metabolism · 2010
DOI 10.1210/jc.2010-1971
cross-sectional · n=46Cited 53×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- In overweight subjects, the concentrations of C2 acylcarnitine (AC) and long-chain ACs are positively associated with percent fat and insulin sensitivity.Strong
- A greater improvement in insulin sensitivity with weight loss during caloric restriction plus exercise may be related to improved coupling of β-oxidation and tricarboxylic acid cycle flux induced by exercise.Strong
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