Research
Metabolic adaptation
Higher variability of body mass index (BMI) is associated with a significantly increased risk of all-cause mortality, cardiovascular deaths, and cardiovascular events in individuals with type 2 diabetes in the control group.
Practitioners should monitor BMI variability in patients with type 2 diabetes as it may indicate higher risks for adverse cardiovascular outcomes.
StrongSupportsmedium confidence
In the control group, the hazard ratios (HRs) for the highest quartile (quartile 4) compared with the lowest quartile (quartile 1) of CV of BMI were 4.06 (95% CI, 2.17-7.57), 15.28 (95% CI, 2.89-80.90), and 2.16 (95% CI, 1.21-3.87) for all-cause mortality, CVD mortality, and cardiovascular events, respectively.
Why this rating
Based on the prospective cohort study design.
Source
Body Weight Variability and Risk of Cardiovascular Outcomes and Death in the Context of Weight Loss Intervention Among Patients With Type 2 Diabetes
Arnaud D. Kazé et al. · JAMA Network Open · 2022
cohort · n=3604Cited 52×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →