Research
Metabolic adaptation
In the intensive lifestyle intervention group, higher variability of BMI is not associated with increased risks of all-cause mortality, cardiovascular deaths, or cardiovascular events.
Intensive lifestyle interventions may mitigate the risks associated with BMI variability in patients with type 2 diabetes.
StrongRefutesmedium confidence
In the intervention group, the corresponding HRs were 0.99 (95% CI, 0.45-2.16), 1.14 (95% CI, 0.12-10.53), and 0.77 (95% CI, 0.40-1.49) for quartile 4 vs quartile 1.
Why this rating
Based on the prospective cohort study design.
Source
Body Weight Variability and Risk of Cardiovascular Outcomes and Death in the Context of Weight Loss Intervention Among Patients With Type 2 Diabetes
Arnaud D. Kazé et al. · JAMA Network Open · 2022
cohort · n=3604Cited 52×
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