Research
Energy balance
Nonelderly females with overweight and obesity experience a reduction in skeletal muscle mass of about 1 to 1.5 kg per 10-kg weight loss during voluntary caloric restriction.
Practitioners should be aware that caloric restriction can lead to significant muscle loss in females, which may need to be addressed in weight loss programs.
StrongSupportsmedium confidence
Nonelderly males and females with overweight and obesity experience respective reductions in SM mass with voluntary CR in the absence of a structured exercise program of about 2 to 2.5 kg and 1 to 1.5 kg per 10-kg weight loss, respectively.
Why this rating
Based on the study design involving longitudinal monitoring and a large sample size.
Source
Proportion of caloric restriction‐induced weight loss as skeletal muscle
Steven B. Heymsfield et al. · Obesity · 2023
DOI 10.1002/oby.23910
cohort · n=897Cited 42×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Nonelderly males with overweight and obesity experience a reduction in skeletal muscle mass of about 2 to 2.5 kg per 10-kg weight loss during voluntary caloric restriction.Strong
- Model predictions of relative skeletal muscle changes with caloric restriction were validated in longitudinal studies.Strong
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