Research
Neural
Testosterone replacement therapy (TR) did not increase aggression in adult male patients with Prader-Willi syndrome.
TR may be safely administered without concerns for increased aggression in this population.
StrongSupportsmedium confidence
The MOAS was unchanged, from 4.5 ± 2.0 at the beginning of the study to 3.0 ± 1.7 at the end of study indicating no increase in aggression.
Why this rating
Based on the observational study design with a clear behavioral assessment.
Source
Testosterone replacement therapy to improve secondary sexual characteristics and body composition without adverse behavioral problems in adult male patients with Prader–Willi syndrome: An observational study
Yasuhiro Kido et al. · American Journal of Medical Genetics Part A · 2013
cohort · n=22Cited 41×
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