Research
Metabolic adaptation
High glycemic load (GL) is associated with greater coronary heart disease (CHD) risk, with a hazard ratio (HR) of 1.16 for the highest vs. lowest quintile and HR of 1.18 per 50 g/day of GL intake.
Practitioners should consider the impact of high glycemic load foods on heart disease risk.
StrongSupportsmedium confidence
High GL was associated with greater CHD risk [HR 1.16 (95% CI: 1.02, 1.31) highest vs. lowest quintile, p-trend 0.035; HR 1.18 (95% CI: 1.07, 1.29) per 50 g/day of GL intake].
Why this rating
Based on the large prospective cohort study design.
Source
Glycemic index, glycemic load, and risk of coronary heart disease: a pan-European cohort study
Sabina Sieri et al. · American Journal of Clinical Nutrition · 2020
cohort · n=338325Cited 37×
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