Energy balance
Intentional, medically supervised weight loss in overweight patients with type 2 diabetes does not reduce all-cause mortality or cardiovascular morbidity and may be associated with increased mortality in obese subgroups (BMI ≥30).
For overweight patients with type 2 diabetes, aiming for significant weight loss under medical supervision does not guarantee a longer life and may not reduce heart disease risk. Focus on stable management of blood sugar, blood pressure, and lipids rather than prioritizing weight loss as the primary goal for longevity.
successful therapeutic intentional weight loss, supervised by a doctor over six years, was not associated with reduced all-cause mortality or cardiovascular morbidity/mortality during the succeeding 13 years.
Why this rating
Population-based cohort study with long follow-up (13 years post-intervention) and rigorous adjustment for confounders, though observational design limits causal inference compared to RCTs.
Source
Intentional Weight Loss and Longevity in Overweight Patients with Type 2 Diabetes: A Population-Based Cohort Study
Rasmus Køster‐Rasmussen et al. · PLoS ONE · 2016
DOI 10.1371/journal.pone.0146889
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