Research
Energy balance
The treatment with GLP-1 RA resulted in a reduction in the risk of any cardiovascular event with a relative risk of 0.81.
The relative risk indicates a significant benefit of GLP-1 RA in reducing cardiovascular events.
StrongSupportsmedium confidence
Treatment with GLP-1 RA versus placebo resulted in a reduction in the risk of any cardiovascular event (RR = 0.81, CI 0.70-0.92; p = .001).
Why this rating
Based on a meta-analysis of placebo-controlled randomized controlled trials.
Source
Effect of glucagon‐like peptide‐1 receptor agonists on cardiovascular events in overweight or obese adults without diabetes: A meta‐analysis of placebo‐controlled randomized trials
Ana Rita Leite et al. · Diabetes Obesity and Metabolism · 2022
DOI 10.1111/dom.14707
Meta-analysisCited 34×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →