Research
Metabolic adaptation
>10% weight loss is strongly associated with major macrovascular events (HR, 1.75; 95% CI, 1.26-2.44) in patients with type 2 diabetes.
>10% weight loss in patients with type 2 diabetes should prompt further cardiovascular risk assessment.
StrongSupportsmedium confidence
Over the following 3 years of the trial, >10% weight loss was strongly associated with major macrovascular events (hazard ratio [HR], 1.75; 95% confidence interval [CI], 1.26-2.44),
Why this rating
Based on study design from abstract.
Source
The Risks of Cardiovascular Disease and Mortality Following Weight Change in Adults with Diabetes: Results from ADVANCE
Alexandra K. Lee et al. · The Journal of Clinical Endocrinology & Metabolism · 2019
rct · n=10081Cited 34×
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