Research
Energy balance
There is unlikely to be an increase in the very low incidence of suicide-related adverse events among individuals receiving GLP-1 receptor agonists within the context of randomized controlled trials.
Healthcare providers can continue to prescribe GLP-1 RAs without heightened concern for suicidality in clinical settings.
StrongRefutesmedium confidence
There is unlikely to be an increase in the very low incidence of suicide-related adverse events among individuals receiving GLP-1 RAs within the context of RCTs.
Why this rating
Based on the systematic review of randomized clinical trials.
Source
Suicide and Self-Harm Events With GLP-1 Receptor Agonists in Adults With Diabetes or Obesity
Pouya Ebrahimi et al. · JAMA Psychiatry · 2025
DOI 10.1001/jamapsychiatry.2025.0091
rct · n=59396Cited 29×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The incidence of completed or attempted suicide and occurrences of suicidal ideation or self-harm is very low in individuals receiving GLP-1 receptor agonists (0.047 per 100 person-years) compared to placebo (0.042 per 100 person-years), with no statistically significant difference.Strong
- Subgroup analyses did not suggest differences in outcomes based on diabetes status or GLP-1 receptor agonist used.Strong
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