Research
Metabolic adaptation
Treatment with SAR425899 resulted in a smaller reduction in body composition-adjusted sleeping metabolic rate (SMR) compared to placebo (p = 0.002).
SAR425899 may help mitigate metabolic adaptation during weight loss.
StrongSupportsmedium confidence
The SAR425899 group had a smaller reduction in body composition-adjusted SMR (p = 0.002) as compared with placebo.
Why this rating
Based on the randomized controlled trial design.
Source
<scp>Glucagon‐like peptide</scp>‐1/glucagon receptor agonism associates with reduced metabolic adaptation and higher fat oxidation: A randomized trial
Karen D. Corbin et al. · Obesity · 2023
rct · n=35Cited 26×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →