Research
Metabolic adaptation
ΔMfn2 stimulates gluconeogenesis in mouse liver and hepatoma cells.
This suggests that manipulating Mfn2 could enhance glucose production in the liver.
StrongSupportsmedium confidence
The expression of ΔMfn2 in mouse liver or in hepatoma cells stimulated gluconeogenesis.
Why this rating
Based on the experimental findings presented in the abstract.
Source
A form of mitofusin 2 (Mfn2) lacking the transmembrane domains and the COOH-terminal end stimulates metabolism in muscle and liver cells
Jessica Segalés et al. · American Journal of Physiology-Endocrinology and Metabolism · 2013
otherCited 27×
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