Research
Molecular
Semaglutide attenuated cardiac inflammation through restoring RKIP expression and inhibiting the TBK1-NF-κB pathway.
Understanding this mechanism can help in developing targeted therapies for cardiac inflammation in diabetes.
StrongSupportsmedium confidence
More significantly, semaglutide attenuated cardiac inflammation through restoring Raf kinase inhibitor protein (RKIP) expression and inhibiting downstream TANK-binding kinase 1 (TBK1)-NF-κB pathway.
Why this rating
Based on the experimental approach involving animal studies.
Source
Semaglutide protects against diabetes‐associated cardiac inflammation via Sirt3‐dependent RKIP pathway
Kaibin Lin et al. · British Journal of Pharmacology · 2024
otherCited 26×
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