Research
Molecular
Semaglutide attenuated cardiac inflammation through restoring RKIP expression and inhibiting the TBK1-NF-κB pathway.
Understanding this mechanism can help in developing targeted therapies for cardiac inflammation in diabetes.
StrongSupportsmedium confidence
More significantly, semaglutide attenuated cardiac inflammation through restoring Raf kinase inhibitor protein (RKIP) expression and inhibiting downstream TANK-binding kinase 1 (TBK1)-NF-κB pathway.
Why this rating
Based on the experimental approach involving animal studies.
Source
Semaglutide protects against diabetes‐associated cardiac inflammation via Sirt3‐dependent RKIP pathway
Kaibin Lin et al. · British Journal of Pharmacology · 2024
DOI 10.1111/bph.17327
otherCited 26×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Semaglutide alleviated metabolic disorders, ameliorated myocardial fibrosis, improved cardiac function, antagonized oxidative stress, and suppressed cardiomyocyte apoptosis in diabetic mice.Strong
- Semaglutide's anti-inflammatory effect is mediated through the Sirt3-dependent RKIP pathway, rather than glucose lowering.Strong
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