Research
Molecular
Semaglutide's anti-inflammatory effect is mediated through the Sirt3-dependent RKIP pathway, rather than glucose lowering.
This suggests that semaglutide may have benefits beyond just lowering blood sugar in diabetic patients.
StrongSupportsmedium confidence
We also found that cAMP/PKA signalling, rather than glucose lowering, contributed to the anti-inflammatory effect of semaglutide through Sirt3-dependent RKIP pathway.
Why this rating
Based on the experimental approach involving animal studies.
Source
Semaglutide protects against diabetes‐associated cardiac inflammation via Sirt3‐dependent RKIP pathway
Kaibin Lin et al. · British Journal of Pharmacology · 2024
DOI 10.1111/bph.17327
otherCited 26×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Semaglutide alleviated metabolic disorders, ameliorated myocardial fibrosis, improved cardiac function, antagonized oxidative stress, and suppressed cardiomyocyte apoptosis in diabetic mice.Strong
- Semaglutide attenuated cardiac inflammation through restoring RKIP expression and inhibiting the TBK1-NF-κB pathway.Strong
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