Research
Molecular
Semaglutide's anti-inflammatory effect is mediated through the Sirt3-dependent RKIP pathway, rather than glucose lowering.
This suggests that semaglutide may have benefits beyond just lowering blood sugar in diabetic patients.
StrongSupportsmedium confidence
We also found that cAMP/PKA signalling, rather than glucose lowering, contributed to the anti-inflammatory effect of semaglutide through Sirt3-dependent RKIP pathway.
Why this rating
Based on the experimental approach involving animal studies.
Source
Semaglutide protects against diabetes‐associated cardiac inflammation via Sirt3‐dependent RKIP pathway
Kaibin Lin et al. · British Journal of Pharmacology · 2024
otherCited 26×
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