Research
Metabolic adaptation
Tirzepatide resulted in mean waist circumference reductions ranging from 4.3 to 9.8 cm across subgroups.
Tirzepatide is effective in reducing waist circumference in East Asian individuals with type 2 diabetes.
StrongSupportsmedium confidence
Mean waist circumference reductions ranged from 4.3 to 9.8 cm.
Why this rating
Based on the phase 3 clinical trial data presented in the abstract.
Source
Safety and efficacy analyses across age and body mass index subgroups in East Asian participants with type 2 diabetes in the phase 3 tirzepatide studies ( <scp>SURPASS</scp> programme)
Arihiro Kiyosue et al. · Diabetes Obesity and Metabolism · 2022
DOI 10.1111/dom.14952
rctCited 24×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Tirzepatide induced a mean absolute HbA1c reduction across the three doses ranging from 2.3% to 3.0% in East Asian participants with type 2 diabetes.Strong
- The safety profile of tirzepatide was broadly similar across BMI and age subgroups, but drug discontinuation due to adverse events was higher in participants aged ≥ 65 years.Strong
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