Research
Metabolic adaptation
Total meal replacement showed greater improvement in HbA1c, FBG, body weight, and BMI compared to partial meal replacement.
Total meal replacement may be more effective than partial meal replacement for improving health markers in T2D patients.
StrongSupportsmedium confidence
Total MR showed greater improvement in HbA1c (-0.72% vs -0.32%; P = .01), FBG (-1.45 vs -0.56 mmol/L; P = .02), body weight (-6.57 vs -1.58 kg; P < .001), and BMI (-2.78 vs -0.37; P < .001) than partial MR.
Why this rating
Based on a meta-analysis of 17 RCTs involving 2112 participants.
Source
Efficacy and Safety of Meal Replacement in Patients With Type 2 Diabetes
Wenjing Ye et al. · The Journal of Clinical Endocrinology & Metabolism · 2023
DOI 10.1210/clinem/dgad273
Meta-analysisCited 14×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Meal replacement (MR) significantly reduced glycated hemoglobin A1c (HbA1c) by -0.46%, fasting blood glucose (FBG) by -0.62 mmol/L, body weight by -2.43 kg, and body mass index (BMI) by -0.65 compared to conventional diabetic diets (CDs).Strong
- Meal replacement with caloric restriction resulted in greater reductions in body weight and BMI compared to meal replacement without caloric restriction.Strong
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