Research
Energy balance
Meal replacement with caloric restriction resulted in greater reductions in body weight and BMI compared to meal replacement without caloric restriction.
Incorporating caloric restriction into meal replacement strategies can enhance weight loss outcomes for T2D patients.
StrongSupportsmedium confidence
MR with caloric restriction showed more reduction in body weight (-3.20 vs -0.75 kg; P < .001) and BMI (-0.84 vs -0.24; P = .003) compared with those without caloric restriction.
Why this rating
Based on a meta-analysis of 17 RCTs involving 2112 participants.
Source
Efficacy and Safety of Meal Replacement in Patients With Type 2 Diabetes
Wenjing Ye et al. · The Journal of Clinical Endocrinology & Metabolism · 2023
DOI 10.1210/clinem/dgad273
Meta-analysisCited 14×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Meal replacement (MR) significantly reduced glycated hemoglobin A1c (HbA1c) by -0.46%, fasting blood glucose (FBG) by -0.62 mmol/L, body weight by -2.43 kg, and body mass index (BMI) by -0.65 compared to conventional diabetic diets (CDs).Strong
- Total meal replacement showed greater improvement in HbA1c, FBG, body weight, and BMI compared to partial meal replacement.Strong
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
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