Research
Energy balance
There were no significant changes in peak VO2 or other cardiovascular measures with HU6 treatment.
HU6 may not improve cardiovascular function despite weight loss.
StrongRefutesmedium confidence
There were no statistically significant changes in peak VO2, 6-minute walk distance, Kansas City Cardiomyopathy Questionnaire score, high-sensitivity C-reactive protein level, N-terminal pro-brain natriuretic peptide level, or diastolic function.
Why this rating
Based on a randomized clinical trial design.
Source
Novel Controlled Metabolic Accelerator for Obesity-Related HFpEF
Ambarish Pandey et al. · JAMA Cardiology · 2025
DOI 10.1001/jamacardio.2025.0103
rct · n=66Cited 12×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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