Research
Molecular
Ex-DARPin fusion proteins have a comparable half-life of 29-32 hours, which is much longer than that of native Ex (0.5 hours in rats).
Longer half-life of Ex-DARPin fusion proteins may reduce the frequency of administration needed for effective treatment.
StrongSupportsmedium confidence
The Ex-DARPin fusion proteins had a comparable half-life (29-32 h), which is much longer than that of native Ex (0.5 h in rats).
Why this rating
Based on the experimental design involving in vivo testing.
Source
Albumin-binding DARPins as scaffold improve the hypoglycemic and anti-obesity effects of exendin-4 in vivo
Jinying Xia et al. · European Journal of Pharmaceutical Sciences · 2023
otherCited 10×
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