Research
Cellular
Ex-DARPin fusion proteins significantly improved the survival of pancreatic islets in diabetic mice.
Improving pancreatic islet survival could enhance insulin production and overall diabetes management.
StrongSupportsmedium confidence
Histological analysis of pancreatic tissues using H&E staining revealed that Ex-DARPin fusion proteins significantly improved the survival of pancreatic islets in diabetic mice.
Why this rating
Based on the experimental design involving histological analysis.
Source
Albumin-binding DARPins as scaffold improve the hypoglycemic and anti-obesity effects of exendin-4 in vivo
Jinying Xia et al. · European Journal of Pharmaceutical Sciences · 2023
DOI 10.1016/j.ejps.2023.106422
otherCited 10×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Ex-DARPin fusion proteins injected at 25 nmol/kg every three days significantly lowered blood glucose, inhibited food consumption, and reduced body weight for 30 days in STZ-induced diabetic mice.Strong
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