Research
Energy balance
Oral semaglutide, 50 mg, led to a mean percentage change in body weight of -14.3% compared to -1.3% with placebo.
Oral semaglutide is effective for significant weight loss in this population.
StrongSupportsmedium confidence
The mean (SEM) percentage change in body weight was -14.3% (0.8) with semaglutide vs -1.3% (1.1) with placebo.
Why this rating
Based on a randomized clinical trial design.
Source
Oral Semaglutide in an East Asian Population With Overweight or Obesity, With or Without Type 2 Diabetes
Takashi Kadowaki et al. · JAMA Internal Medicine · 2025
rct · n=201Cited 9×
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