Research
Energy balance
84.3% of participants on semaglutide achieved a 5% or greater body weight reduction compared to 17.2% on placebo.
A high proportion of patients on semaglutide can expect significant weight loss.
StrongSupportsmedium confidence
More participants had 5% or greater body weight reductions with semaglutide vs placebo (107 of 127 [84.3%] vs 11 of 64 [17.2%]).
Why this rating
Based on a randomized clinical trial design.
Source
Oral Semaglutide in an East Asian Population With Overweight or Obesity, With or Without Type 2 Diabetes
Takashi Kadowaki et al. · JAMA Internal Medicine · 2025
rct · n=201Cited 9×
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