Research
Metabolic adaptation
There is no clear evidence that GLP-1RAs and dual GLP-1/GIPRA enhance cardiorespiratory fitness (CRF).
Practitioners should be cautious in expecting improvements in CRF from these therapies.
StrongRefutesmedium confidence
clinical studies have failed to show improvements in CRF, a critical determinant of long-term cardiovascular health.
Why this rating
The claim is based on clinical studies referenced in the abstract.
Source
Incretin Receptor Agonism, Fat-free Mass, and Cardiorespiratory Fitness: A Narrative Review
Zhenqi Liu et al. · The Journal of Clinical Endocrinology & Metabolism · 2025
reviewCited 9×
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