Research
Cellular
GLP-1RAs and dual GLP-1/GIPRA are associated with notable reductions in fat-free mass (FFM).
Practitioners should monitor FFM loss in patients undergoing GLP-1RA and GLP-1/GIPRA therapies.
StrongSupportsmedium confidence
recent trials show GLP-1RAs and dual GLP-1/GIPRA therapy accelerates FFM loss.
Why this rating
The claim is supported by recent trials mentioned in the abstract.
Source
Incretin Receptor Agonism, Fat-free Mass, and Cardiorespiratory Fitness: A Narrative Review
Zhenqi Liu et al. · The Journal of Clinical Endocrinology & Metabolism · 2025
DOI 10.1210/clinem/dgaf335
reviewCited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Cellular
- Athletes aiming to reduce fat mass and preserve FFM should consume protein intakes in the range of ∼1.8-2.7 g kg(-1) d(-1).Strong
- A minimum daily protein intake of ≥1.6 g/kg is necessary to observe significant improvements in muscle mass from whey protein supplementation.Strong
- Most athletes ideally need 1.2 to 2.0 grams/kg of body weight/day of protein, preferably split across 3-4 meals.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →