Research
Molecular
Mendelian randomisation did not find evidence that genetically proxied GLP-1RA increased suicide attempts in a general population cohort.
There is no genetic evidence to support an association between GLP-1RA and increased suicide attempts, suggesting safety in this regard.
StrongRefutesmedium confidence
MR did not find evidence genetically proxied GLP1RA increased SA in a general population cohort.
Why this rating
Based on the use of Mendelian randomisation, which is a robust study design.
Source
Glucagon‐like‐peptide 1 receptor agonism and attempted suicide: A Mendelian randomisation study to assess a potential causal association
Anthony Nguyen et al. · Clinical Obesity · 2024
DOI 10.1111/cob.12676
otherCited 8×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Molecular
- QRISK decreased markedly after weight loss from 18.9 ± 2.2% to 11.2 ± 1.6%, p < 0.0001.Strong
- Normalization of 10-year cardiovascular risk and heart age is possible after substantial dietary weight loss and remission of T2DM.Strong
- The Low-Fat Plus diet resulted in a greater reduction in total cholesterol compared to the Low-Fat diet, with changes of -0.46 mmol/L (-17.6 mg/dL) versus -0.24 mmol/L (-9.2 mg/dL) respectively (P = 0.01).Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →