Research
Energy balance
One-year discontinuation rates for GLP-1 receptor agonists can be as high as 74% in real-world studies.
Healthcare providers should be aware of the high discontinuation rates of GLP-1 RAs in real-world settings.
StrongSupportsmedium confidence
Real-world studies report one-year discontinuation rates as high as 74%, though substantial variability exists between studies.
Why this rating
Based on a systematic review and meta-analysis of real-world studies.
Source
Glucagon‐like peptide‐1 receptor agonists discontinuation is higher in individuals with overweight and obesity without type 2 diabetes
Gregory J. Grosicki et al. · Diabetes Obesity and Metabolism · 2025
DOI 10.1111/dom.16151
Meta-analysisCited 7×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →