Research
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Discontinuation of GLP-1 receptor agonists can lead to rapid weight regain and loss of cardiometabolic benefits.
Maintaining adherence to GLP-1 RA therapy is crucial for sustained weight loss and health benefits.
StrongSupportsmedium confidence
Rapid weight regain and an attenuation of cardiometabolic benefits (e.g., blood pressure, glycaemic status, blood lipids) are often observed when patients discontinue GLP-1 RAs.
Why this rating
Based on observations noted in the abstract.
Source
Glucagon‐like peptide‐1 receptor agonists discontinuation is higher in individuals with overweight and obesity without type 2 diabetes
Gregory J. Grosicki et al. · Diabetes Obesity and Metabolism · 2025
DOI 10.1111/dom.16151
Meta-analysisCited 7×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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