Research
Energy balance
Discontinuation of GLP-1 receptor agonists can lead to rapid weight regain and loss of cardiometabolic benefits.
Maintaining adherence to GLP-1 RA therapy is crucial for sustained weight loss and health benefits.
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Rapid weight regain and an attenuation of cardiometabolic benefits (e.g., blood pressure, glycaemic status, blood lipids) are often observed when patients discontinue GLP-1 RAs.
Why this rating
Based on observations noted in the abstract.
Source
Glucagon‐like peptide‐1 receptor agonists discontinuation is higher in individuals with overweight and obesity without type 2 diabetes
Gregory J. Grosicki et al. · Diabetes Obesity and Metabolism · 2025
Meta-analysisCited 7×
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