Research
Energy balance
There is limited evidence supporting the effectiveness of n-3-PUFA supplementation in improving or preventing loss of lean mass in both younger and older healthy adults, as well as clinical populations including oncologic patients.
Practitioners should be cautious in recommending n-3-PUFA supplementation for lean mass improvement.
StrongRefutesmedium confidence
Our analysis indicates limited evidence supporting the effectiveness of n-3-PUFA supplementation in both younger and older healthy adults, as well as clinical populations including oncologic patients, to improve or prevent loss of lean mass.
Why this rating
Based on the overview of systematic reviews.
Source
Lack of evidence for Omega-3 fatty acid supplementation in enhancing lean mass, muscle strength, and physical function in healthy adults and clinical populations: An overview of reviews
Everson Araújo Nunes et al. · Clinical Nutrition ESPEN · 2025
DOI 10.1016/j.clnesp.2025.03.012
Meta-analysisCited 5×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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