Research
Energy balance
Cognitive outcome is not a limitation for the use of calorie restriction for health improvement.
Health practitioners can recommend CR without fear of adverse cognitive effects.
StrongSupportsmedium confidence
Our null findings suggest that cognitive outcome is not a limitation for the use of CR for health improvement.
Why this rating
Based on a multi-center, randomized controlled trial design.
Source
CALERIE II: the effect of 25% calorie restriction over two years on cognitive function (629.7)
Tammy Scott et al. · The FASEB Journal · 2014
DOI 10.1096/fasebj.28.1_supplement.629.7
rct · n=218Cited 5×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →