Research
Metabolic adaptation
After 5 weeks of a very low-calorie ketogenic diet (VLCKD), patients with Cushing's disease (CD) experienced a significant decrease in BMI (p=0.002), waist circumference (WC) (p=0.024), systolic (p=0.015) and diastolic blood pressure (p=0.005), ACTH (p=0.026), cortisone (p=0.025), total (p=0.006) and LDL cholesterol (p=0.017), triglycerides (p=0.016), alkaline phosphatase (p=0.008) and a significant increase in HDL cholesterol (p=0.017), vitamin D (p=0.015) and oral disposition index (Dio)(p=0.004).
Implementing a VLCKD may significantly improve metabolic health in patients with Cushing's disease.
StrongSupportsmedium confidence
After 5 weeks of diet a significant decrease in BMI (p=0.002), waist circumference (WC) (p=0.024), systolic (p=0.015) and diastolic blood pressure (p=0.005), ACTH (p=0.026), cortisone (p=0.025), total (p=0.006) and LDL cholesterol (p=0.017), triglycerides (p=0.016), alkaline phosphatase (p=0.008) and a significant increase in HDL cholesterol (p=0.017), vitamin D (p=0.015) and oral disposition index (Dio)(p=0.004) was observed in CD.
Why this rating
The study involves a controlled evaluation of dietary effects on a specific patient group.
Source
Nutritional Intervention in Cushing’s Disease: The Ketogenic Diet Effects on Metabolic Comorbidities and Adrenal Steroids
Valentina Guarnotta et al. · Preprints.org · 2023
DOI 10.20944/preprints202310.0431.v1
cohort · n=30Cited 6×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A significant decrease in BMI (p=0.003), waist circumference (p=0.002), systolic (p=0.025) and diastolic blood pressure (p=0.007) and total cholesterol (p=0.026) and increase in HDL cholesterol (p=0.001) and oral disposition index (Dio)(p<0.001) was observed in controls after the diet.Strong
- The study confirms that a ketogenic diet is effective in improving metabolic disorders and can be combined with conventional therapy for Cushing's disease.Strong
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