Research
Energy balance
AOM-naïve patients experienced superior weight loss outcomes with semaglutide compared to non-AOM-naïve patients at 3, 6, 9, and 12 months.
Practitioners should consider that patients who have not previously used anti-obesity medications may achieve better weight loss results with semaglutide.
StrongSupportsmedium confidence
Outcomes of semaglutide treatment were superior in AOM-naïve patients (n = 231) compared to non-AOM-naïve patients (n = 74) at 3 (6.3% vs. 3.8%), 6 (10.6% vs. 6.7%), 9 (14.0% vs. 9.1%) and 12 months (14.3% vs. 10.6%; p < 0.0001 at 3, 6 and 9 months, and p = 0.01 at 12 months).
Why this rating
Based on the retrospective study design with a substantial sample size.
Source
The association between previous use of <scp>anti‐obesity</scp> medication and semaglutide weight loss outcomes
Wissam Ghusn et al. · Diabetes Obesity and Metabolism · 2024
DOI 10.1111/dom.15523
cohort · n=305Cited 5×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →