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A greater proportion of AOM-naïve patients achieved ≥15% and ≥20% total body weight loss at 12 months compared to non-AOM-naïve patients.
Clinicians should note that AOM-naïve patients are more likely to achieve significant weight loss with semaglutide.
StrongSupportsmedium confidence
A greater proportion of patients in the AOM-naïve group achieved a TBWL ≥ 15% (48% vs 21%; p = 0.02) and ≥20% (27% vs 4% p < 0.01) at 12 months.
Why this rating
Based on the retrospective study design with a substantial sample size.
Source
The association between previous use of <scp>anti‐obesity</scp> medication and semaglutide weight loss outcomes
Wissam Ghusn et al. · Diabetes Obesity and Metabolism · 2024
DOI 10.1111/dom.15523
cohort · n=305Cited 5×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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