Research
Metabolic adaptation
Individuals with Friedreich's ataxia (FRDA) have lower insulin sensitivity (whole-body insulin sensitivity index 2.8 vs 5.3, P < .01) compared to controls.
Practitioners should be aware that FRDA is associated with reduced insulin sensitivity, which may impact metabolic health.
StrongSupportsmedium confidence
Individuals with FRDA had lower insulin sensitivity (whole-body insulin sensitivity index 2.8 vs 5.3, P < .01).
Why this rating
Based on study design from abstract.
Source
Insulin Sensitivity and Insulin Secretion in Adults With Friedreich's Ataxia: The Role of Skeletal Muscle
Jaclyn Tamaroff et al. · The Journal of Clinical Endocrinology & Metabolism · 2024
DOI 10.1210/clinem/dgae545
case_control · n=35Cited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Friedreich's ataxia (FRDA) individuals exhibit higher postprandial insulin secretion (insulin secretory rate incremental area under the curve 30-180 minutes, 24,652 vs 17,858, P < .05) compared to controls.Strong
- Lower mitochondrial oxidative phosphorylation (OXPHOS) capacity and inactivity contribute to lower insulin sensitivity in individuals with Friedreich's ataxia (FRDA).Strong
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