Research
Cellular
Lower mitochondrial oxidative phosphorylation (OXPHOS) capacity and inactivity contribute to lower insulin sensitivity in individuals with Friedreich's ataxia (FRDA).
Improving mitochondrial function and physical activity may enhance insulin sensitivity in FRDA patients.
StrongSupportsmedium confidence
In regression analyses, lower OXPHOS and inactivity explained some of the difference in insulin sensitivity.
Why this rating
Based on study design from abstract.
Source
Insulin Sensitivity and Insulin Secretion in Adults With Friedreich's Ataxia: The Role of Skeletal Muscle
Jaclyn Tamaroff et al. · The Journal of Clinical Endocrinology & Metabolism · 2024
DOI 10.1210/clinem/dgae545
case_control · n=35Cited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Individuals with Friedreich's ataxia (FRDA) have lower insulin sensitivity (whole-body insulin sensitivity index 2.8 vs 5.3, P < .01) compared to controls.Strong
- Friedreich's ataxia (FRDA) individuals exhibit higher postprandial insulin secretion (insulin secretory rate incremental area under the curve 30-180 minutes, 24,652 vs 17,858, P < .05) compared to controls.Strong
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