Browse the evidence

A semisupervised high-intensity interval training (HIT) intervention did not increase menstrual frequency in women with polycystic ovary syndrome (PCOS).

Practitioners should note that HIT may not be effective for improving menstrual frequency in women with PCOS.

The postoperative incidence of beneficial effects and complications from RYGB varies across patient subgroups with different preoperative characteristics.

Individualized assessment of patients is crucial to optimize RYGB outcomes and minimize complications.

Severe adverse effects with GLP-1 RA use are not uncommon and warrant further close monitoring.

Practitioners should closely monitor patients for severe adverse effects when initiating GLP-1 RA therapy.

There is an ongoing debate over the role of pharmacotherapy versus interventional approaches in treating obesity and MASLD in liver transplantation.

Clinicians should stay informed about evolving treatment options for obesity and MASLD.

Experience with GLP-1 agonists in patients with obesity and inflammatory skin diseases is currently scarce.

Further research is needed to establish the efficacy and safety of GLP-1 agonists in this specific population.

The use of semaglutide in patients with previous intake of other AOMs was associated with inferior weight loss outcomes.

Healthcare providers should be cautious when prescribing semaglutide to patients with a history of AOM use, as they may not achieve optimal weight loss.

There is a need for a dedicated trial to examine the benefits of semaglutide in type 1 diabetes.

Further research is warranted to validate the effects of semaglutide in type 1 diabetes.

Tirzepatide has a generally safe profile with possible mild-to-moderate gastrointestinal side effects.

Healthcare providers should monitor patients for gastrointestinal side effects when prescribing tirzepatide.

Neither chia flour nor whey protein supplementation elicited an enhanced effect on fat-free mass (FFM) and strength gains after an 8-week resistance training program.

Supplementing with chia flour or whey protein does not provide additional benefits for body composition or strength in young men already consuming a high protein diet.

Global consumption of ultra-processed foods (UPFs) has increased dramatically.

Practitioners should be aware of the rising trend in UPF consumption.

No additional benefits were observed for ∑MT.

Practitioners should note that increasing volume may not benefit all measures of training outcomes.

There are inadequacies in the measures used to qualify obesity.

Practitioners should be aware of the limitations in current obesity measures when assessing health risks.

There is a need to determine intermediate factors and mechanisms connecting excess adiposity and health.

Identifying these factors can enhance targeted interventions for obesity-related health issues.

No significant associations were found between white rice intake and risk of cardiovascular diseases, CVD mortality, cancer, and metabolic syndrome.

Practitioners can inform patients that white rice does not appear to significantly impact these other health risks.

Long-term cardiovascular outcome data for recent anti-obesity medications remain inconclusive or lacking.

Practitioners should be cautious and consider the lack of long-term data when prescribing these medications.

Moorehead-Ardelt scores were higher in the bypass group at 2 years but showed no statistically significant differences later on.

Practitioners should note that while bypass may improve certain quality of life metrics initially, this effect may not persist long-term.

JMV-449 inhibited food intake in overnight fasted lean mice.

JMV-449 may be useful in appetite regulation strategies for weight management.

Obesity is a global epidemic and a chronic, progressive disease.

Recognizing obesity as a chronic disease can influence treatment approaches.

Tirzepatide has a half-life of five days, allowing for once-weekly administration.

Practitioners can schedule tirzepatide administration once a week due to its five-day half-life.

The amount of excess weight reduction after bariatric surgery varies by procedure, with laparoscopic adjustable gastric banding reducing excess weight by 49% and Roux-en-Y gastric bypass by 76%.

Practitioners should inform patients about expected weight loss outcomes based on the type of surgery.

No competitor characteristic predicted any of the resistance training variables manipulated during peak week.

Competitors may not need to tailor their training adjustments based on individual characteristics during peak week.

There is a significant multiplicative interaction of cardiovascular autonomic neuropathy (CAN) and sex on both mortality outcomes.

Understanding the interaction between CAN and sex can improve risk assessment and management strategies in diabetes care.

Most adverse events (AEs) associated with incretin-based therapies (IBTs) are mild or moderate and mainly occur during dose escalation.

Clinicians should monitor patients for mild to moderate AEs, especially during dose increases.

Replacing sugar-sweetened beverages (SSB) with non-caloric beverages (artificially sweetened (ASB) or unsweetened (USB)) had no effect on pre-specified cardiovascular disease (CVD) risk factors.

Practitioners should note that switching to non-caloric beverages may not improve CVD risk factors.