Browse the evidence

Preoperative use of GLP-1 receptor agonists is associated with reduced rates of periprosthetic joint infection (PJI) and hospital readmission in patients undergoing total hip and knee arthroplasty, particularly among those with diabetes or morbid obesity.

If you are taking a GLP-1 RA (like Ozempic or Wegovy) before hip or knee replacement surgery, current evidence suggests it may lower your risk of joint infection and hospital readmission, especially if you have diabetes or obesity. However, because these drugs cause rapid weight loss, your surgical team must carefully monitor your nutritional status (e.g., albumin levels) to ensure you are not malnourished, which could increase complication risks. Do not stop the medication without consulting your surgeon, as the net benefit appears positive in many cases, but close monitoring is essential.

Epitalon, a tetrapeptide, extends cellular lifespan by activating telomerase and lengthening telomeres, while also modulating pineal gland function to restore melatonin synthesis.

Epitalon is an investigational peptide that may extend cellular lifespan by activating telomerase and restoring melatonin production. While animal studies show promising lifespan extension, human data is limited to small studies without long-term safety validation. It is not FDA-approved for anti-aging.

BPC-157 and TB-500 enhance tissue repair and angiogenesis in aged tissues, showing promise in small pilot studies for chronic pain and wound healing.

BPC-157 and TB-500 are peptides that may help heal tissues, tendons, and muscles by promoting blood vessel growth and reducing inflammation. Small studies suggest they can relieve chronic pain and heal wounds, but they are not FDA-approved for these uses, and long-term safety is unknown.

Semax enhances neuroplasticity and cognitive function in aging by upregulating BDNF and modulating neurotransmitter systems, showing benefits in stroke recovery and cognitive decline.

Semax is a peptide that may improve brain health by increasing BDNF, a key factor in neuroplasticity. Russian studies suggest it can help stroke recovery and cognitive function, but it is not FDA-approved for these uses, and independent Western validation is lacking.

The report makes recommendations about terminology and a classification scheme for dietary carbohydrates.

Practitioners should consider the recommended terminology and classification when discussing dietary carbohydrates.

The report includes recommendations on the minimum dietary energy intake from carbohydrates.

Practitioners should consider the recommended minimum dietary energy intake from carbohydrates in dietary planning.

Diabetes, obesity and cardiorenal/metabolic disease often occur in the same patient.

Healthcare providers should be aware of the interconnectedness of these conditions in patients.

Early intensive combination intervention can prevent disease progression and events.

Implementing early and intensive interventions may improve patient outcomes.

Suboptimal metabolic control has not improved in past 20 years despite new medications.

There is a need for improved strategies to manage metabolic control in patients.

GLP-1 agonists have drawbacks in treating obesity.

Practitioners should be aware of the limitations of GLP-1 agonists in obesity treatment.

An alternative approach to GLP-1 agonist treatment includes long-term lifestyle programming.

Incorporating lifestyle changes alongside GLP-1 treatment may enhance effectiveness.

The approach of 'Food Is Medicine' is suggested to address obesity burdens.

Utilizing appropriate food choices can be a key strategy in obesity management.

Animal-based proteins should represent the majority (i.e., ≥65%) of protein intake during active cancer treatment.

Clinicians should prioritize animal-based protein sources for patients with cancer.

A diet rich in plant-derived proteins may support muscle anabolism in cancer but requires a larger quantity of protein.

Patients may include more plant proteins in their diet, but they need to ensure adequate intake.

Initiating an exclusively plant-based (i.e., vegan) diet upon a diagnosis of cancer may pose risks due to elevated protein requirements.

Patients should avoid vegan diets immediately after a cancer diagnosis to meet protein needs.

The American College of Sports Medicine (ACSM) acknowledges that lawful and ethical therapeutic use of anabolic-androgenic steroids (AAS) is now an accepted mainstream treatment for several clinical disorders.

Practitioners should recognize AAS as a legitimate treatment option for certain clinical conditions.

There is increased recognition that AAS are commonly used illicitly to enhance performance and appearance in several segments of the population.

Awareness of AAS misuse is crucial for health professionals and athletes alike.

Ultrasonography is recommended as the initial screening tool for hepatic steatosis in Latin America.

Practitioners should use ultrasonography for initial screening of MASLD patients.

Complete alcohol abstinence is recommended for patients with significant fibrosis.

Practitioners should advise patients with significant fibrosis to abstain from alcohol.

Bariatric surgery has been the primary approach to treating obese individuals.

Practitioners should consider bariatric surgery as a primary treatment option for obesity.

Long-term results with semaglutide and tirzepatide are approaching the success seen with bariatric surgery.

Practitioners should be aware of the effectiveness of semaglutide and tirzepatide in weight management.

The relationship between saturated and unsaturated fat consumption and coronary heart disease (CHD) risk is controversial and confusing.

Practitioners should be aware of the ongoing debate regarding dietary fat recommendations.

The symposium aimed to summarize key scientific evidence regarding dietary fats and CHD risk.

The symposium provided a platform for discussing scientific evidence on dietary fats.

Stacking some supplements may provide additional benefits, but can also lead to unintentional ingredient doubling.

Athletes should be cautious about stacking to avoid negative interactions.