Browse the evidence

Mathematical models can help design and predict the results of key new experiments to fill knowledge gaps.

Practitioners can use mathematical models to inform the design of experiments aimed at addressing knowledge gaps in obesity and metabolism.

The reanalysis ignored the within-participant, repeated-measures structure of the data.

Understanding the importance of proper statistical methods is crucial for accurate dietary research interpretation.

The reanalysis reported incorrect statistical comparisons and optimistic p-values.

Practitioners should critically evaluate statistical results in dietary studies to avoid misinterpretation.

There is no current method to quantitatively estimate the permanent changes in diet or physical activity required to prevent weight regain.

Practitioners should be aware of the lack of quantitative tools for estimating necessary lifestyle changes for weight maintenance.

There was no interaction between glycogen content and exercise intensity.

Exercise intensity does not modify the effect of glycogen content on metabolism as previously thought.

More people around the world now have obesity than suffer from starvation.

This indicates a need for urgent public health interventions to address obesity.

The energy available in the United States food supply increased much more than population needs.

This suggests that dietary guidelines should address energy intake relative to needs.

Substantial investments in coordinated nutrition and agricultural research are needed to transform the food system.

This highlights the importance of policy and research in addressing obesity and food security.

There is a need for reform in laws governing corporations to hold them accountable.

Practitioners should engage in advocacy for corporate accountability in food marketing.

70% of respondents disagreed that current SNAP benefit levels were adequate to maintain a healthy diet.

Practitioners should consider advocating for increased SNAP benefits to support healthier diets.

Activation of the mitogen-activated protein kinase signalling cascade has been proposed as a possible mechanism involved in the regulation of many of the exercise-induced adaptations in skeletal muscle.

Understanding this mechanism can help in designing effective training programs.

A total of 1026 girls have been flagged for potential eligibility in the RCT over a 2-year period.

This indicates the feasibility of recruiting participants for dietary studies in PCOS.

Medication use was the most frequent reason for exclusion from the study, affecting 26% of flagged girls.

Practitioners should be aware that medication use may limit eligibility for dietary interventions in PCOS.

The genetic risk score (GRS) was associated with incident coronary heart disease (CHD) across cohorts, with a relative risk (RR) of 1.59 (95% CI: 1.41-1.79) for the highest quintile compared to the lowest.

Genetic risk factors significantly contribute to the likelihood of developing CHD, highlighting the importance of genetic screening.

No significant findings emerged in White women, African American men, or for the 8-10 week outcomes or for waist-to-hip ratio adjusted for body mass index (WHRadjBMI).

Practitioners should be cautious in generalizing findings across different demographic groups.

Receiving e-messages had no significant effect on adherence to low-carbohydrate or low-fat diets.

The e-message intervention did not enhance adherence to specific dietary plans, indicating a need for more effective strategies.

Dietary content impacts health and aging in mice.

Understanding dietary impacts can guide interventions for aging in humans.

Households in low-income countries spend a considerable proportion of their income on food, approximately half.

Understanding food expenditure can help in designing interventions for better nutrition.

The database serves as a tool for evaluating evidence linking specific fibers with health outcomes.

Practitioners can use this database to find evidence-based information on dietary fibers.

Early treatment with the DPP-4 inhibitor, sitagliptin, did not lead to better glycemic control than placebo and did not prevent posttransplant diabetes (PTD).

Practitioners should reconsider the use of sitagliptin for preventing PTD in kidney transplant patients.

The study failed to observe a statistically significant difference in the primary efficacy measure of ≥20 mg/dl difference in the 2-h OGTT at 3 months.

The lack of significant difference suggests that sitagliptin may not be effective in improving glucose tolerance in this population.

The potential effect of sitagliptin on blood glucose was lost by month 6 after treatment discontinuation.

This suggests that continuous treatment may be necessary to maintain glycemic control.

Monogenic obesity is rare and caused by mutations in a single gene.

Recognizing the rarity of monogenic obesity can help in accurate diagnosis and treatment.

Tirzepatide is a GIP receptor and GLP-1 receptor agonist.

Understanding the mechanism can help in predicting the drug's effects and potential interactions.