Research
Molecular
The genetic risk score (GRS) was associated with incident coronary heart disease (CHD) across cohorts, with a relative risk (RR) of 1.59 (95% CI: 1.41-1.79) for the highest quintile compared to the lowest.
Genetic risk factors significantly contribute to the likelihood of developing CHD, highlighting the importance of genetic screening.
StrongSupportsmedium confidence
The GRS was associated with incident CHD (n = 3001 cases) across each cohort (pooled GRS quintile (Q)5 vs Q1, RR (95% CI): 1.59 (1.41-1.79)).
Why this rating
The study involves pooled analyses from multiple cohorts.
Source
Abstract P094: Genetic Risk, Incident Coronary Heart Disease Events, and the Benefits of a Healthy Lifestyle: Joint and Interacting Effects Across Four US Cohorts
Liana C. Del Gobbo et al. · Circulation · 2017
cohort · n=22412
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