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A healthy lifestyle score was more strongly associated with CHD than the genetic risk score, with a relative risk of 1.94 (95% CI: 1.71-2.20) for the highest quintile compared to the lowest.
Promoting a healthy lifestyle is crucial for reducing the risk of CHD, potentially more so than focusing solely on genetic factors.
StrongSupportsmedium confidence
The lifestyle score was more strongly associated with CHD (pooled Q1 vs Q5, RR: 1.94 (1.71-2.20)) than the GRS.
Why this rating
The study involves pooled analyses from multiple cohorts.
Source
Abstract P094: Genetic Risk, Incident Coronary Heart Disease Events, and the Benefits of a Healthy Lifestyle: Joint and Interacting Effects Across Four US Cohorts
Liana C. Del Gobbo et al. · Circulation · 2017
DOI 10.1161/circ.135.suppl_1.p094
cohort · n=22412
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The genetic risk score (GRS) was associated with incident coronary heart disease (CHD) across cohorts, with a relative risk (RR) of 1.59 (95% CI: 1.41-1.79) for the highest quintile compared to the lowest.Strong
- Interactions between the genetic risk score and dietary factors, specifically trans fats, were observed, indicating that the effects of trans fats on CHD risk are more pronounced in individuals with a higher genetic risk score.Strong
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