Browse the evidence

Lifestyle modifications remain the primary approach to managing MASLD, but their effectiveness is often limited.

Practitioners should be aware of the limitations of lifestyle modifications in MASLD management.

Incretin analogs are preferred for overweight or obese patients according to the American Gastroenterological Association.

Providers should consider these guidelines when treating overweight or obese patients.

Nutritional therapists are too rarely consulted despite the significant effects of diet on cardiovascular risk factors.

Practitioners should consider involving nutritional therapists in treatment plans for dyslipidemias.

Recent studies support the plausibility and evidence of individual nutritional measures for dyslipidemias.

Practitioners should stay updated on recent studies regarding nutritional interventions for dyslipidemias.

Weight gain increases the risk for atherosclerosis regardless of cardiovascular events status or overweight/obese at baseline.

Practitioners should be aware that weight gain is a significant risk factor for atherosclerosis.

A higher proportion of carbohydrate intake is associated with an increased risk of cardiovascular disease and all-cause mortality in Japanese people with type 2 diabetes.

Practitioners should consider the carbohydrate intake levels of patients with type 2 diabetes when assessing cardiovascular risk.

The mean total low-carbohydrate diet score and animal low-carbohydrate diet score are inversely associated with the incidence of cardiovascular events and all-cause mortality.

Encouraging low-carbohydrate dietary patterns may benefit patients with type 2 diabetes in reducing cardiovascular risk.

The study utilized a multivariable Cox proportional hazards model to analyze the relationship between lifestyle habits and health outcomes.

Understanding the methodology can help practitioners evaluate the reliability of the findings.

Resistance training practitioners frequently consume excessive protein and protein supplements (primarily whey) driven by aesthetic goals, despite evidence that intakes above ~1.6 g/kg/day do not further increase muscle mass.

You likely do not need protein supplements to build muscle. Focus on getting 1.6 grams of protein per kilogram of body weight daily from whole foods. If you are already hitting this number through food, adding whey protein powder provides no additional muscle-building benefit and wastes money. Prioritize carbohydrates for energy during workouts instead.

GLP-1 agonists may provide additional benefits beyond weight loss and diabetes management.

Providers should explore the broader implications of GLP-1 agonists for patients with various conditions.

Combining GLP-1 RAs with EBTs may yield synergistic effects.

Practitioners may explore combination therapies for enhanced weight loss outcomes.

72.2% of patients achieved ≥ 20% total weight loss (TWL) by week 52 on liraglutide.

Practitioners can expect a significant proportion of patients to achieve substantial weight loss with liraglutide.

Liraglutide was well-tolerated, with benefits experienced by over 90% of patients.

Liraglutide can be considered a safe option for obesity management in clinical practice.

Patients achieved a calorie deficit of 651 kcal/day while on liraglutide.

Practitioners should encourage calorie tracking to support weight loss efforts in patients using liraglutide.

Individuals without diabetes were more likely to achieve ≥10% weight loss compared to individuals with T2D (21.4% vs. 0%).

Practitioners may consider the likelihood of achieving significant weight loss when prescribing tirzepatide based on diabetes status.

The basic principles of healthy nutrition remain largely unchanged over the years.

Practitioners should focus on established nutritional guidelines rather than trends.

Ingesting 4.5g of Alaska Pollack Protein (APP) daily for 3 months improves neuromuscular efficiency (neural economy) in young healthy adults, evidenced by a greater reduction in motor unit discharge rates compared to whey protein, without increasing muscle mass.

If you are a young, healthy adult looking to improve how efficiently your muscles generate force, adding just 4.5 grams of Alaska Pollack Protein to your daily diet for 3 months may help. You likely won't see your muscles get bigger, but your nervous system may become more efficient at producing force, allowing you to generate the same strength with less neural effort compared to taking whey protein.

Lifestyle approaches to manage antipsychotic-induced weight gain are recommended but have limitations.

Practitioners should be aware of the limitations of lifestyle interventions in this population.

Observational studies show reduced mortality rates among participants with higher physical activity levels compared to those with less activity.

Encouraging higher physical activity levels may contribute to lower mortality rates.

Abdominal adiposity is linked to increased mortality in Mexicans.

Health practitioners should consider abdominal adiposity as a significant risk factor for mortality in their assessments.

Ultrasound measurement of vastus lateralis (VL) muscle thickness, combined with body mass, provides a statistically accurate and ecologically valid prediction of whole-body and thigh fat-free mass (FFM) in resistance-trained men, serving as a viable alternative to DXA.

If you are a resistance-trained man, you can track your muscle gains using a portable ultrasound device focused on your vastus lateralis (side thigh) and your body weight. The study provides a specific formula: Whole Body FFM = -1.657 + (0.719 * Body Mass in kg) + (0.416 * VL Thickness in mm). This method is as accurate as DXA for this group and can be done in a gym setting, allowing you to monitor progress without expensive medical imaging.

Adhering to a hypercaloric, high-protein plant-based diet during resistance training preserves insulin sensitivity (HOMA-IR) and prevents the rise in fasting serum insulin seen with an isoenergetic, isonitrogenous omnivorous diet.

If you are eating enough protein (around 2g per kg of body weight) and training hard, choosing a plant-based diet rich in mycoprotein (like Quorn) can help keep your insulin sensitivity stable. You don't need to worry about the metabolic downsides often associated with high-protein diets, as long as you match the calories and protein of an omnivorous diet.

A high-protein plant-based diet does not compromise micronutrient status (Vitamin B12, Vitamin D, Calcium, Ferritin) compared to an omnivorous diet during resistance training, although ferritin levels may decrease in both groups.

You can follow a high-protein plant-based diet without worrying about losing essential vitamins and minerals, as long as you eat enough calories and protein. Just be aware that your ferritin (iron storage) might drop, which is also true for omnivores in this study, so monitor your levels if you feel fatigued.

Protein supplementation improves endurance performance and muscle strength compared to placebo, but these benefits are likely attributable to unmatched energy intake rather than protein itself.

If you are an athlete, protein supplements may help performance, but likely only because they add calories. If you already meet your energy needs, adding protein powder on top of it may not offer extra performance gains compared to a placebo with the same calories. Focus on total energy intake first.